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Pollen is gathered from flowers grown in Sweden.
Each grain's tough outer shell, where the allergens sit, is taken away.
The cytoplasm inside is concentrated into Pure CyTonin®.
“I’m Dr. Steven Goldstein, an OB/GYN and Professor at NYU Grossman School of Medicine. I’ve spent decades helping women navigate menopause with informed, individualized care. As a clinical advisor to FEM by UPSA, I’m helping bring that same standard of scientific rigor to its engagement with U.S. healthcare professionals.”
"I'm Dr. Valentina Elisabetta Bounous, a gynecologist and PhD researcher at the University of Turin, Italy.
Throughout my career, I've focused on translating clinical research into better care for women. That's why I value evidence-based, non-hormonal options like FEM by UPSA that can help address the diverse needs of women during perimenopause and menopause."
"I'm Dr. Amanda Corbett, a Clinical Pharmacist, integrative health professional, and Associate Professor at the UNC Eshelman School of Pharmacy with over 25 years of pharmacy and research expertise focused on supplement safety.
Perimenopause and menopause symptoms can impact daily life in very real ways, and no woman deserves to, or should, 'just live with it.' FEM from UPSA's commitment to education and evidence-backed solutions can help make those conversations more informed and productive for patients.
Too many women feel they must simply 'live with' the symptoms of perimenopause and menopause. I'm excited about FEM from UPSA's science-driven approach that helps educate women about clinically studied, non-hormonal options and aims to support informed, productive conversations with their healthcare professionals."
| Compare |
FEM
|
Hormone therapy | Phytoestrogen supplements | Prescription non-hormonal medicines |
|---|---|---|---|---|
| No hormones or plant estrogens | ✓ None of either 5 | × Contains hormones | × Contains plant estrogens | ✓ None of either |
| No prescription needed | ✓ Order online | × Prescription only | ✓ Over the counter | × Prescription only |
| Tested against a placebo | ✓ Double-blind, placebo-controlled studies 1 2 | ✓ Large clinical trials | − Mixed results 7 | ✓ Clinical trials 7 |
| Studied in breast cancer survivors | ✓ Placebo-controlled trial, 2024 2 | × Generally not advised after breast cancer | − Limited data | − Some options |
| Well tolerated in studies | ✓ Yes.Well tolerated 2 | − Known risks can include blood clots and stroke | ✓ Usually mild | − Can include nausea, dizziness or drowsiness |
| Made by a pharmaceutical company | ✓ UPSA, France, since 1935 | ✓ Prescription medicine | − Varies by brand | ✓ Prescription medicine |
No. There are no hormones in FEM, and no plant estrogens either. In lab testing, Pure CyTonin® showed no estrogen-like activity.
If you're still having periods, even irregular ones, take Perimeno. If it's been 12 months since your last period, take Meno. If you have bladder issues, take Urovital.
Some women notice a change in the first few weeks. In the studies, women took it daily for 8 to 12 weeks, so we suggest giving it at least two months.
FEM doesn't contain hormones, and it has been tested in a small placebo-controlled study of breast cancer survivors.2 Please talk to your oncology team before you start, especially if you're taking tamoxifen or an aromatase inhibitor.
The part of the pollen that causes allergies is removed. If you have a pollen allergy, check with your doctor before you start.
In double-blind, placebo-controlled studies, women who took FEM daily for 8 to 12 weeks saw a 68% reduction in hot flashes, 62% in night sweats, 56% in fatigue, 60% in irritability and 50% in sleep problems.1 A separate placebo-controlled trial in breast cancer survivors found significantly fewer hot flashes after three months.2
All FEM products are made in France by UPSA with 90+ years of pharmaceutical expertise.
† These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
